Protein Family Models

This domain is structurally very similar [1] to the creatinase N-terminal domain (Pfam:PF01321). However, little or no sequence similarity exists between the two families. [1]. 9520390. Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli. Wilce MC, Bond CS, Dixon NE, Freeman HC, Guss JM, Lilley PE, Wilce JA;. Proc Natl Acad Sci U S A 1998;95:3472-3477. (from Pfam)

Date:

2024-10-16

This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3]. The structure of a representative of this family. [1]. 8471602. Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme. Roderick SL, Matthews BW. Biochemistry 1993;32:3907-3912. -!- Members of this family are metallopeptidases. They belong to family M24 in the classification of Rawlings and Barrett. [2]. 7674922. Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ;. Meth Enzymol 1995;248:183-228. [3]. 18579787. The FACT Spt16 "peptidase" domain is a histone H3-H4 binding module. Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K, Ladurner AG;. Proc Natl Acad Sci U S A. 2008;105:8884-8889. (from Pfam)

Date:

2024-10-16

Gene:

pepP

Date:

2021-08-05