Protein Family Models

Date:

2024-08-14

Date:

2024-08-14

This domain represents the RNA polymerase binding domain of NusA. [1]. 11430821. An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA. Worbs M, Bourenkov GP, Bartunik HD, Huber R, Wahl MC;. Mol Cell 2001;7:1177-1189. (from Pfam)

Date:

2024-10-16

The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure. Structure and an extension of S1 family. [1]. 9008164. The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold. Bycroft M, Hubbard TJ, Proctor M, Freund SM, Murzin AG;. Cell 1997;88:235-242. (from Pfam)

Date:

2024-10-16

This HMM describes NusA, or N utilization substance protein A, a bacterial transcription termination factor. It binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures. It is named for the interaction in E. coli of phage lambda antitermination protein N with the N-utilization substance, consisting of NusA, NusB, NusE (ribosomal protein S10), and nusG. This model represents a region of NusA shared in all bacterial forms, and including an S1 (PF00575) and a KH (PF00013) RNA binding domains. Proteobacterial forms have an additional C-terminal region, not included in this model, with two repeats of a 50-residue domain rich in acidic amino acids.

Gene:

nusA

Date:

2024-05-16

NusA is a bacterial transcription termination factor. It is named for its interaction with phage lambda protein N, as part of the N utilization substance. Some members of the NusA family have a long C-terminal extension. This HMM represents an acidic 50-residue region found in two copies toward the C-terminus of most Proteobacterial NusA proteins, spaced about 26 residues apart. Analogous C-terminal extensions in some other bacterial lineages lack apparent homology but appear similarly acidic.

Gene:

nusA

Date:

2019-09-10

transcription termination/antitermination protein NusA binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA, and participates in both transcription termination and antitermination

Date:

2024-10-03