Protein Family Models

This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC [1,2]. [1]. 8648624. Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82. Mahdi AA, Sharples GJ, Mandal TN, Lloyd RG;. J Mol Biol 1996;257:561-573. [2]. 7813450. Processing of intermediates in recombination and DNA repair: identification of a new endonuclease that specifically cleaves Holliday junctions. Sharples GJ, Chan SN, Mahdi AA, Whitby MC, Lloyd RG;. EMBO J 1994;13:6133-6142. (from Pfam)

Date:

2024-10-16

This HMM describes the founding member of the family, the crossover junction endodeoxyribonuclease RusA of the DLP12 prophage region in Escherichia coli K-12, and closely related proteins. More distantly related proteins should be called RusA family crossover junction endodeoxyribonuclease, not RusA per se.

Gene:

rusA

Date:

2023-01-13