Protein Family Models

This is an alpha helical domain with a conserved ExxARxxE motif that is found in polyvalent proteins of both conjugative elements and phages and prophages [1]. [1]. 28559295. Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;. J Bacteriol. 2017; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

CLCAs, named for calcium-activated chloride channel bCLCA1, are proteins that resemble certain zinc-dependent metalloproteases in fold by lacking the signature HEXXH motifs. The CLCA_X family, described by this model, was identified based on weak similarities by Lenart, et al. as a notable CLCA-like family with a consistent architecture. The C-terminal half of the CLCA_X family was later described as the LPD1 domain (Large polyvalent protein-associated domain 1 - see PF18796) in a study of domains found within a variety of different architectures in larger proteins of phage and conjugative elements.

Date:

2023-07-14