BKACE, beta-keto acid cleavage enzyme plays, a role in lysine degradation. In certain instances it catalyses the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA [1]. The family is found to have at least 14 slightly different potential new enzymatic activities, all of which can therefore be designated as beta-keto acid cleavage enzymes [2]. [1]. 21632536. 3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation. Bellinzoni M, Bastard K, Perret A, Zaparucha A, Perchat N, Vergne C, Wagner T, de Melo-Minardi RC, Artiguenave F, Cohen GN, Weissenbach J, Salanoubat M, Alzari PM;. J Biol Chem. 2011;286:27399-27405. [2]. 24240508. Revealing the hidden functional diversity of an enzyme family. Bastard K, Smith AA, Vergne-Vaxelaire C, Perret A, Zaparucha A, De Melo-Minardi R, Mariage A, Boutard M, Debard A, Lechaplais C, Pelle C, Pellouin V, Perchat N, Petit JL, Kreimeyer A, Medigue C, Weissenbach J, Artiguenave F, De Berardinis V, Vallenet D, Salanoubat M;. Nat Chem Biol. 2014;10:42-49. (from Pfam)
GO Terms:- Molecular Function:
- transferase activity (GO:0016740)
- Biological Process:
- L-lysine catabolic process to acetate (GO:0019475)
- Molecular Function:
- 3-keto-5-aminohexanoate cleavage activity (GO:0043720)
- Date:
- 2024-10-16