Protein Family Models

ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localisation, is associated with EMT in human cancerous tissue [1]. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras [2]. [1]. 16959614. ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H;. Cancer Cell. 2006;10:227-239. [2]. 19015638. ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F, Huber H, Csiszar A, Beug H, Mikulits W;. Oncogene. 2009;28:638-650. (from Pfam)

Date:

2024-10-16

The founding member of this protein is phage lambda tail tip protein J, which confers host specificity by binding to E. coli protein LamB (maltoporin), the lambda receptor.

Date:

2024-11-04

This HMM hits a central region of bacterial phage host specificity protein J of phage lambda, a tail protein whose C-terminal region binds a host protein that serves as a phage receptor.

Date:

2024-08-14

Members of this family of functionally uncharacterised domains are found in various bacteriophage host specificity proteins. (from Pfam)

Date:

2024-08-14