Protein Family Models

ABC transporter permease from the MlaE family is the transmembrane subunit (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters; these transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment; the captured solute is delivered to a gated translocation pathway formed by the two TMs

Date:

2024-02-09

MlaE is a permease which in E. coli is a component of the Mla pathway, an ABC transport system that functions to maintain the asymmetry of the outer membrane [1]. In Swiss:Q7DD59 it is involved in L-glutamate import into the cell [2]. In Swiss:Q8L4R0 it is involved in lipid transfer within the cell [2]. [1]. 19383799. An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane. Malinverni JC, Silhavy TJ;. Proc Natl Acad Sci U S A. 2009;106:8009-8014. [2]. 16495545. Identification of a meningococcal L-glutamate ABC transporter operon essential for growth in low-sodium environments. Monaco C, Tala A, Spinosa MR, Progida C, De Nitto E, Gaballo A, Bruni CB, Bucci C, Alifano P;. Infect Immun. 2006;74:1725-1740. [3]. 12743031. A permease-like protein involved in ER to thylakoid lipid transfer in Arabidopsis. Xu C, Fan J, Riekhof W, Froehlich JE, Benning C;. EMBO J. 2003;22:2370-2379. (from Pfam)

Date:

2024-10-16

This HMM describes a subfamily of ABC transporter permease subunits. One member of this family has been associated with the toluene tolerance phenotype of Pseudomonas putida, another with L-glutamate transport, another with maintenance of lipid asymmetry. Many bacterial species have one or two members. The Mycobacteria have large paralogous families included in the DUF140 family but excluded from this subfamily on based on extreme divergence at the amino end and on phylogenetic and UPGMA trees on the more conserved regions.

Date:

2019-09-10