Protein Family Models

M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1]. This domain is found in the centre of the Mga proteins. This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci. These proteins have been shown to regulate the expression of important bacterial adhesins [2]. This is presumably a DNA-binding domain. [1]. 11952907. Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus. McIver KS, Myles RL;. Mol Microbiol 2002;43:1591-1601. [2]. 11988525. Group A streptococcal RofA-type global regulators exhibit a strain-specific genomic presence and regulation pattern. Kreikemeyer B, Beckert S, Braun-Kiewnick A, Podbielski A;. Microbiology 2002;148:1501-1511. (from Pfam)

Date:

2024-10-16