Protein Family Models

This domain is the periplasmic domain of the GspL/EpsL family proteins. These proteins are involved in type II secretion systems. (from Pfam)

Date:

2024-08-14

This family consists of Type II secretion system protein L sequences from several Gram-negative (diderm) bacteria. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. T2SL is predicted to contain a large cytoplasmic domain represented by this family and has been shown to interact with the autophosphorylating cytoplasmic membrane protein T2SE. It is thought that the tri-molecular complex of T2SL, T2SE (Pfam:PF00437) and T2SM (Pfam:PF04612) might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation [1]. [1]. 10322014. Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae. Sandkvist M, Hough LP, Bagdasarian MM, Bagdasarian M;. J Bacteriol 1999;181:3129-3135. [2]. 15533433. The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily. Abendroth J, Bagdasarian M, Sandkvist M, Hol WG;. J Mol Biol 2004;344:619-633. [2]. 15223057. The general secretory pathway: a general misnomer?. Desvaux M, Parham NJ, Scott-Tucker A, Henderson IR;. Trends Microbiol. 2004;12:306-309. [3]. 14600218. Type II protein secretion and its relation. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

This HMM represents GspL, protein L of the type II secretion system, which previously was called the main terminal branch of the General Secretion Pathway. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens.

Gene:

gspL

Date:

2024-05-30