Protein Family Models

This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596. (from Pfam)

Date:

2025-02-03

Proteins with only the short N-terminal methylation site are not separated from the noise. The Prosite pattern detects those better. (from Pfam)

Date:

2025-02-01

type IV pilin protein similar to Pseudomonas aeruginosa type IV pilus (T4P) non-core minor pilin PilE, an ssential component of the T4P that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, twitching, adhesion, and retraction of T4P fibers

Date:

2025-01-06

This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14).

Date:

2019-09-10