Protein Family Models

This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes. The domain is often found in conjunction with Pfam:PF01262. Pyridine nucleotide transhydrogenase catalyses the reduction of NAD+ to NADPH. A complete loss of activity occurs upon mutation of Gly314 in E. coli [1]. [1]. 1633824. A mutation at Gly314 of the beta subunit of the Escherichia coli pyridine nucleotide transhydrogenase abolishes activity and affects the NADP(H)-induced conformational change. Ahmad S, Glavas NA, Bragg PD;. Eur J Biochem 1992;207:733-739. (from Pfam)

Date:

2024-10-16

NAD(P)(+) transhydrogenase (Re/Si-specific) subunit beta is part of a tetrameric membrane-bound proton pump (composed of two alpha and two beta subunits) that catalyzes the reversible transfer of a hydride ion equivalent between NAD and NADP

Date:

2018-01-10