Protein Family Models

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 323 to 658 amino acids in length. (from Pfam)

Date:

2024-08-14

Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalysing trans-esterification [1-3]. This entry represents the nuclease domain of VirD2 and similar sequences. [1]. 9350859. Nicking by transesterification: the reaction catalysed by a relaxase. Byrd DR, Matson SW;. Mol Microbiol 1997;25:1011-1022. [2]. 10940031. Identification of the mob genes of plasmid pSC101 and characterization of a hybrid pSC101-R1162 system for conjugal mobilization. Meyer R;. J Bacteriol 2000;182:4875-4881. [3]. 10482518. Bacterial conjugation protein MobA mediates integration of complex DNA structures into plant cells. Bravo-Angel AM, Gloeckler V, Hohn B, Tinland B;. J Bacteriol 1999;181:5758-5765. (from Pfam)

Date:

2024-10-16

relaxase/mobilization nuclease domain-containing protein may function in relaxation complex formation and plasmid mobilization by conjugative plasmids; similar to Helicobacter pylori VirD2-like relaxase protein

Date:

2021-09-02