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ESX secretion-associated protein EspG
This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread [2]. Proteins in this family are typically between 254 and 295 amino acids in length. [1]. 16368961. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles O, Butcher PD, Leclerc C, Cole ST, Brosch R;. Infect Immun. 2006;74:88-98. [2]. 17433643. A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis. Teutschbein J, Schumann G, Mollmann U, Grabley S, Cole ST, Munder T;. Microbiol Res. 2009;164:253-259. (from Pfam)
ESX secretion-associated protein EspG is a cytoplasmic chaperone specific for the type VII secretion system, ESAT-6 secretion system (ESX); EspG plays an important role in preventing aggregation of PE/PPE dimers
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