Protein Family Models

This is the N-terminal domain of tRNA (adenine(58)-N(1))- methyltransferase TrmI, a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [1]. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity. [1]. 11554794. Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv. Gupta A, Kumar PH, Dineshkumar TK, Varshney U, Subramanya HS;. J Mol Biol. 2001;312:381-391. [2]. 26189113. The m1A(58) modification in eubacterial tRNA: An overview of tRNA recognition and mechanism of catalysis by TrmI. Degut C, Ponchon L, Folly-Klan M, Barraud P, Tisne C;. Biophys Chem. 2016;210:27-34. [3]. 12682365. Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures. Droogmans L, Roovers M, Bujnicki JM, Tricot C, Hartsch T, Stalon V, Grosjean H;. Nucleic Acids Res. 2003;31:2148-2156. (from Pfam)

Date:

2024-10-16

GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [1]. [1]. 9851972. The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. Anderson J, Phan L, Cuesta R, Carlson BA, Pak M, Asano K, Bjork GR, Tamame M, Hinnebusch AG;. Genes Dev 1998;12:3650-3662. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Date:

2017-07-21