Protein Family Models for Protein (Select 1914091048) - Protein Family Models

Select item 4261651.

This is the C-terminal helicase domain of ERCC3, RAD25 and XPB helicases [1]. [1]. 23385459. Structure of the C-terminal half of human XPB helicase and the impact of the disease-causing mutation XP11BE. Hilario E, Li Y, Nobumori Y, Liu X, Fan L;. Acta Crystallogr D Biol Crystallogr. 2013;69:237-246. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF027528.5
Method:: HMM

Select item 4224302.

helicase-associated domain-containing protein

This domain family is found in a wide variety of helicases and helicase-related proteins. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF025011.5
Method:: HMM

Select item 4149163.

DEAD/DEAH box helicase family protein

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: ATP binding (GO:0005524)

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2024-08-14

Family Accession:: NF016724.5
Method:: HMM

Select item 4118844.

DEAD/DEAH box helicase

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)

GO Terms:

Molecular Function:: nucleic acid binding (GO:0003676)

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-10-16

Family Accession:: NF012492.5
Method:: HMM

Select item 4117615.

helicase-related protein

The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012493.5
Method:: HMM

Select item 4091476.

DNA repair helicase XPB

Rv0861c and the other members of this family are homologs to the eukarotic DNA repair helicase XPB (ERCC3), and therefore speculated to likewise play a role in some form of DNA repair. A C394F substitution in the family member TP_0380 ortholog from was observed in a Treponema pallidum strain with a somewhat elevated rate of SNP accumulation.

Date:: 2023-11-16

Family Accession:: NF045503.1
Method:: HMM

Select item 4013557.