Protein Family Models

AutA, an autotransporter that was non-functional in early-sequenced strains of Neisseria, is phase-variable because of nucleotide repeats in the signal peptide region. When expressed, it plays a role in autoaggregation and biofilm formation, which may contribute to colonization and persistence in the host.

Gene:

autA

Date:

2020-07-22

A number of Gram-negative bacterial proteins, mostly found in pathogens and associated with virulence, contain a conserved C-terminal domain that integrates into the outer membrane and enables the N-terminal region to be delivered across the membrane. This C-terminal autotransporter domain is about 400 amino acids in length and includes the aromatic amino acid-rich OMP signal, typically ending with a Phe or Trp residue, at the extreme C-terminus.

Date:

2024-06-21

autotransporter outer membrane beta-barrel domain-containing protein similar to Escherichia coli uncharacterized protein YaiT and Bordetella pertussis autotransporter BrkA (Bordetella serum-resistance killing protein A)

Date:

2018-05-02