Protein Family Models

This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates [1]. [1]. 16684886. The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases. Hagelueken G, Adams TM, Wiehlmann L, Widow U, Kolmar H, Tummler B, Heinz DW, Schubert WD;. Proc Natl Acad Sci U S A. 2006;103:7631-7636. (from Pfam)

Date:

2024-10-16

This domain is involved in binding sterols. It is found in the SCP2 protein Swiss:P22307, as well as the C terminus of Swiss:P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Swiss:Q17372 contains an SPFH domain Pfam:PF01145 [2]. [1]. 8243660. NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2. Szyperski T, Scheek S, Johansson J, Assmann G, Seedorf U, Wuthrich K;. FEBS Lett 1993;335:18-26. [2]. 8667025. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S;. J Neurochem 1996;67:46-57. (from Pfam)

Date:

2024-10-16

Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. (from Pfam)

Date:

2024-08-14