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META domain-containing protein
Small domain family found in proteins of of unknown function. Some are secreted (e.g. Swiss:O25998) and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene. Over-expression in L.amazonensis increases virulence (Swiss:O43987; [1]). A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond. [1]. 10403759. Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene. Uliana SR, Goyal N, Freymuller E, Smith DF;. Exp Parasitol 1999;92:183-191. [2]. 12625841. New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor. Yeats C, Bentley S, Bateman A;. BMC Microbiol 2003;3:3-3. (from Pfam)
META domain-containing protein similar to Escherichia coli heat shock protein HslJ
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