Protein Family Models

This entry represents the first PDC (PhoQ/DcuS/CitA) sensor domain found in methyl-accepting chemotaxis proteins (MCPs) such as TLQP and MCPA/B. Paper describing PDB structure 3li8. [1]. 20435045. Structural characterization of the predominant family of histidine kinase sensor domains. Zhang Z, Hendrickson WA;. J Mol Biol. 2010;400:335-353. Paper describing PDB structure 4jgo. [2]. 23436677. Insight into the sporulation phosphorelay: crystal structure of the sensor domain of Bacillus subtilis histidine kinase, KinD. Wu R, Gu M, Wilton R, Babnigg G, Kim Y, Pokkuluri PR, Szurmant H, Joachimiak A, Schiffer M;. Protein Sci. 2013;22:564-576. Paper describing PDB structure 4wy9. [3]. 26923153. The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition. Machuca MA, Liu YC, Beckham SA, Gunzburg MJ, Roujeinikova A;. J Struct Biol. 2016;194:205-213. Paper describing PDB structure 4xmq. [4]. 26457436. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Liu YC, Machuca MA, Beckham SA, Gunzburg MJ, Roujeinikova A;. Acta Crystallogr D Biol Crystallogr. 2015;71:2127-2136. Paper describing PDB structure 5ave. [5]. 26878914. Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants. Nishiyama S, Takahashi Y, Yamamoto K, Suzuki D, Itoh Y, Sumita K, Uchida Y, Homma M, Imada K, Kawagishi I;. Sci Rep. 2016;6:20866. (from Pfam)

Date:

2024-10-16

This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90. [1]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:

2024-10-16

Dimerisation and phospho-acceptor domain of histidine kinases. [1]. 9989504. Structure of CheA, a signal-transducing histidine kinase. Bilwes AM, Alex LA, Crane BR, Simon MI;. Cell 1999;96:131-141. [2]. 18361456. Crystal structure of a novel non-Pfam protein AF1514 from Archeoglobus fulgidus DSM 4304 solved by S-SAD using a Cr X-ray source. Li Y, Bahti P, Shaw N, Song G, Chen S, Zhang X, Zhang M, Cheng C, Yin J, Zhu JY, Zhang H, Che D, Xu H, Abbas A, Wang BC, Liu ZJ;. Proteins 2008;71:2109-13. (from Pfam)

Date:

2024-10-16

This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain. [1]. 7699720. Response regulators of bacterial signal transduction systems: selective domain shuffling during evolution. Pao GM, Saier MH;. J Mol Evol 1995;40:136-154. (from Pfam)

Date:

2024-10-16

two-component hybrid sensor histidine kinase/response regulator with an N-terminal PDC (PhoQ/DcuS/CitA) sensor domain

Date:

2020-01-08