This entry represents transcriptional regulatory proteins in Staphylococcal species including SarA and Rot [1-5]. Sar is a global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors [5]. Paper describing PDB structure 1hsj. [1]. 11381122. Crystal structure of the SarR protein from Staphylococcus aureus. Liu Y, Manna A, Li R, Martin WE, Murphy RC, Cheung AL, Zhang G;. Proc Natl Acad Sci U S A. 2001;98:6877-6882. Paper describing PDB structure 1p4x. [2]. 12837797. Crystal structure of the SarS protein from Staphylococcus aureus. Li R, Manna AC, Dai S, Cheung AL, Zhang G;. J Bacteriol. 2003;185:4219-4225. Paper describing PDB structure 2fnp. [3]. 16455801. Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Liu Y, Manna AC, Pan CH, Kriksunov IA, Thiel DJ, Cheung AL, Zhang G;. Proc Natl Acad Sci U S A. 2006;103:2392-2397. Paper describing PDB structure 4q77. [4]. 25195759. Structure of Rot, a global regulator of virulence genes in Staphylococcus aureus. Zhu Y, Fan X, Zhang X, Jiang X, Niu L, Teng M, Li X;. Acta Crystallogr D Biol Crystallogr. 2014;70:2467-2476. Paper describing PDB structure 4rbr. [5]. 25331435. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence. Killikelly A, Benson MA, Ohneck EA, Sampson JM, Jakoncic . TRUNCATED at 1650 bytes (from Pfam)
- Date:
- 2024-10-28