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pyrBI operon leader peptide
This family consists of the pyrBI operon leader peptides. The expression of the pyrBI operon, which encodes the subunits of the pyrimidine biosynthetic enzyme aspartate transcarbamylase. is regulated primarily through a UTP-sensitive transcriptional attenuation control mechanism. In this mechanism, the concentration of UTP determines the extent of coupling between transcription and translation within the pyrBI leader region, hence determining the level of rho-independent transcriptional termination at an attenuator preceding the pyrB gene [1]. [1]. 7517939. Nucleotide-specific transcriptional pausing in the pyrBI leader region of Escherichia coli K-12. Donahue JP, Turnbough CL Jr;. J Biol Chem 1994;269:18185-18191. (from Pfam)
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