Protein Family Models for Protein (Select 2005385131) - Protein Family Models

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Links from Protein

Items: 4

Select item 4161841.

succinylglutamate desuccinylase/aspartoacylase family protein

This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.). [1]. 8252036. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Kaul R, Gao GP, Balamurugan K, Matalon R;. Nat Genet 1993;5:118-123. (from Pfam)

GO Terms:

Molecular Function:: hydrolase activity, acting on ester bonds (GO:0016788)

Date:: 2024-10-16

Family Accession:: NF016817.5
Method:: HMM

Select item 3916192.

new record, indexing in progress

Family Accession:

Select item 3531323.

new record, indexing in progress

Family Accession:

Select item 519774.

N(2)-acetyl-L-2,4-diaminobutanoate deacetylase DoeB

Members of this family, part of the succinylglutamate desuccinylase / aspartoacylase family (PF04952), belong to ectoine utilization operons, as found in Sinorhizobium meliloti 1021 (where it the operon is known to be induced by ectoine), Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas putida.