Protein Family Models for Protein (Select 2044745870) - Protein Family Models

Select item 4359631.

thiolase family protein such as acetyl-CoA C-acetyltransferase, which catalyzes the transfer of an acetyl group from acetyl-CoA to another molecule of acetyl-CoA to form acetoacetyl-CoA

Date:: 2024-08-01

Family Accession:: 11415132
Method:: Sparcle

Select item 4141652.

Thiolase, C-terminal domain

Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase. [1]. 9402066. The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. Mathieu M, Modis Y, Zeelen JP, Engel CK, Abagyan RA, Ahlberg A, Rasmussen B, Lamzin VS, Kunau WH, Wierenga RK;. J Mol Biol 1997;273:714-728. (from Pfam)

GO Terms:

Molecular Function:: acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)

Date:: 2024-10-16

Family Accession:: NF014820.5
Method:: HMM

Select item 4119713.

Thiolase, N-terminal domain

Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase. [1]. 9402066. The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. Mathieu M, Modis Y, Zeelen JP, Engel CK, Abagyan RA, Ahlberg A, Rasmussen B, Lamzin VS, Kunau WH, Wierenga RK;. J Mol Biol 1997;273:714-728. (from Pfam)

GO Terms:

Molecular Function:: acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)

Date:: 2024-10-16

Family Accession:: NF012336.5
Method:: HMM

Select item 3897824.

new record, indexing in progress

Family Accession:

Select item 3888225.

new record, indexing in progress

Family Accession:

Select item 3489526.

new record, indexing in progress

Family Accession:

Select item 3469487.

new record, indexing in progress

Family Accession:

Select item 1421398.

acetyl-CoA C-acyltransferase

This model represents a large family of enzymes which catalyze the thiolysis of a linear fatty acid CoA (or acetoacetyl-CoA) using a second CoA molecule to produce acetyl-CoA and a CoA-ester product two carbons shorter (or, alternatively, the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA and CoA). This enzyme is also known as "thiolase", "3-ketoacyl-CoA thiolase", "beta-ketothiolase" and "Fatty oxidation complex beta subunit". When catalyzing the degradative reaction on fatty acids the corresponding EC number is 2.3.1.16. The condensation reaction corresponds to 2.3.1.9. Note that the enzymes which catalyze the condensation are generally not involved in fatty acid biosynthesis, which is carried out by a decarboxylating condensation of acetyl and malonyl esters of acyl carrier proteins. Rather, this activity may produce acetoacetyl-CoA for pathways such as IPP biosynthesis in the absence of sufficient fatty acid oxidation.

GO Terms:

Molecular Function:: acetyl-CoA C-acetyltransferase activity (GO:0003985)

Biological Process:: fatty acid metabolic process (GO:0006631)

Date:: 2021-04-27

Family Accession:: TIGR01930.1
Method:: HMM

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