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Metallo-beta-lactamase superfamily domain
This family is part of the metallo-beta-lactamase superfamily. [1]. 17128255. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing. endonuclease.. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley. JL, Tong L;. Nature. 2006;444:953-956. (from Pfam)
Beta-Casp domain
The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains [1]. [1]. 17128255. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing. endonuclease.. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley. JL, Tong L;. Nature. 2006;444:953-956. (from Pfam)
MBL fold metallo-hydrolase RNA specificity domain-containing protein
The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases. This, the fifth motif [1], appears to be specific to Zn-dependent metallohydrolases such as ribonuclease J 2 [4] which are involved in the processing of mRNA [2,3]. This domain adds essential structural elements to the CASP-domain and is unique to RNA/DNA-processing nucleases, showing that they are pre-mRNA 3'-end-processing endonucleases [2,3,4]. [1]. 12177301. Metallo-beta-lactamase fold within nucleic acids processing. enzymes: the beta-CASP family.. Callebaut I, Moshous D, Mornon JP, de Villartay JP;. Nucleic Acids Res 2002;30:3592-3601.. [2]. 17128255. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing. endonuclease.. Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley. JL, Tong L;. Nature. 2006;444:953-956.. [3]. 20544974. Crystal structure of an archaeal cleavage and polyadenylation. specificity factor subunit from Pyrococcus horikoshii.. Nishida Y, Ishikawa H, Baba S, Nakagawa N, Kuramitsu S, Masui R;. Proteins. 2010;78:2395-2398.. [4]. 21764917. Characterization of components of the Staphylococcus aureus mRNA. degradosome holoenzyme-like complex.. Roux CM, DeMuth JP, Dunman PM;. J Bacteriol. 2011;193:5520-5526. (from Pfam)
MBL fold metallo-hydrolase
beta-CASP ribonuclease aCPSF1
archaeal beta-CASP ribonuclease 1 (aCPSF1) is a cleavage and polyadenylation specificity factor (CPSF) similar to methanothermobacter thermautotrophicus MTH1203, a metal-dependent ribonuclease
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