Protein Family Models

This is the N-terminal domain of heparinase II/III proteins. It is a toroid-like domain [1]. [1]. 23011846. Structural basis of heparan sulfate-specific degradation by heparinase III. Dong W, Lu W, McKeehan WL, Luo Y, Ye S;. Protein Cell. 2012;3:950-961. (from Pfam)

Date:

2024-10-16

This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II (Swiss:Q46080) and heparinase III (Swiss:Q59289). The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin [1]. [1]. 8702264. Isolation and expression in Escherichia coli of hepB and hepC, genes coding for the glycosaminoglycan-degrading enzymes heparinase II and heparinase III, respectively, from Flavobacterium heparinum. Su H, Blain F, Musil RA, Zimmermann JJ, Gu K, Bennett DC;. Appl Environ Microbiol 1996;62:2723-2734. [2]. 23011846. Structural basis of heparan sulfate-specific degradation by heparinase III. Dong W, Lu W, McKeehan WL, Luo Y, Ye S;. Protein Cell. 2012;3:950-961. (from Pfam)

Date:

2024-10-16

AlgLyase and Hepar_II_III domain-containing protein

Date:

2019-03-21