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TGF-beta receptor interacting domain-containing protein
This domain is found at the C-terminal end of a group of animal zinc finger FYVE domain-containing proteins, including Smad anchor for receptor activation (SARA), which plays a significant role in TGF-mediated signalling. This domain is involved in the interaction with the TGF-beta receptor [1,2]. This domain is found associated with Pfam:PF01363. [1]. 9865696. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL;. Cell. 1998;95:779-791. [2]. 10615055. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi Y;. Science. 2000;287:92-97. (from Pfam)
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