Protein Family Models

The Swiss Army Knife class of proteins features a diverse domain repertoire acting to repair RNA damaged in the wake of RNase attacks. PTP-SAK is one such domain, a phosphatase of the rhodanese-phosphatase superfamily. It is predicted to 'clean' RNA ends by removing phosphate groups, preparing them for ligation by their associating RNA ligases [1,2]. [1]. 36968430. New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts. Burroughs AM, Aravind L;. NAR Genom Bioinform. 2023;5:lqad029. [2]. 27536007. RNA damage in biological conflicts and the diversity of responding RNA repair systems. Burroughs AM, Aravind L;. Nucleic Acids Res. 2016;44:8525-8555. (from Pfam)

Date:

2024-10-16

This domain occupies the toxin tip position in a subset of polymorphic toxin domains [1,2]. This domain is found at the extreme C-terminal of certain polymorphic toxin-related Tc-like toxins deployed by bacteria against eukaryotic host cells. This position is where the toxin module delivered into the target cells host resides [1]. [1]. 36968430. New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts. Burroughs AM, Aravind L;. NAR Genom Bioinform. 2023;5:lqad029. [2]. 22731697. Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics. Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;. Biol Direct. 2012;7:18. (from Pfam)

Date:

2024-10-16

This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families. (from Pfam)

Date:

2024-08-14

This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner [1,2]. [1]. 8127873. KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases. Hannon GJ, Casso D, Beach D;. Proc Natl Acad Sci U S A 1994;91:1731-1735. [2]. 10987270. Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. Yeh CT, Lu SC, Chen TC, Peng CY, Liaw YF;. Cancer Res 2000;60:4697-4700. (from Pfam)

Date:

2024-10-16