Protein Family Models

Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs [1]. [1]. 16237448. Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover. Callaghan AJ, Marcaida MJ, Stead JA, McDowall KJ, Scott WG, Luisi BF;. Nature. 2005;437:1187-1191. (from Pfam)

Date:

2024-10-16

This model describes ribonuclease G (formerly CafA, cytoplasmic axial filament protein A), the N-terminal domain of ribonuclease E in which ribonuclease activity resides, and related proteins. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5' end of 16S RNA. The C-terminal half of RNase E (excluded from the seed alignment for this model) lacks ribonuclease activity but participates in mRNA degradation by organizing the degradosome.

Date:

2024-05-16