Protein Family Models

This domain is found at the C-terminal end of sulfatases and alkaline phosphatases from bacteria, eukaryotes and archaea, including N-sulphoglucosamine sulphohydrolase from humans (SGSH) and Bifunctional sulfatase/alpha-L-rhamnosidase from Formosa agariphila (P36_S1_25). It shows a four-stranded antiparallel beta-sheet, with four surrounding alpha-helices, followed by a C-terminal extension consisting of a small two-stranded antiparallel beta-sheet [1, 2]. [1]. 31285597. A marine bacterial enzymatic cascade degrades the algal. polysaccharide ulvan.. Reisky L, Prechoux A, Zuhlke MK, Baumgen M, Robb CS, Gerlach N,. Roret T, Stanetty C, Larocque R, Michel G, Song T, Markert S,. Unfried F, Mihovilovic MD, Trautwein-Schult A, Becher D,. Schweder T, Bornscheuer UT, Hehemann JH;. Nat Chem Biol. 2019;15:803-812.. [2]. 24816101. Structure of sulfamidase provides insight into the molecular. pathology of mucopolysaccharidosis IIIA.. Sidhu NS, Schreiber K, Propper K, Becker S, Uson I, Sheldrick. GM, Gartner J, Kratzner R, Steinfeld R;. Acta Crystallogr D Biol Crystallogr. 2014;70:1321-1335. (from Pfam)

Date:

2024-08-14

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2]. [1]. 9344668. Molecular cloning and chromosomal localization of PD-Ibeta. (PDNP3), a new member of the human phosphodiesterase I genes.. Jin-Hua P, Goding JW, Nakamura H, Sano K;. Genomics 1997;45:412-415.. [2]. 8617788. Cloning and expression of the unique Ca2+-ATPase from. Flavobacterium odoratum.. Peiffer WE, Desrosiers MG, Menick DR;. J Biol Chem 1996;271:5095-5100.. [3]. 7730366. Affinity purification and cDNA cloning of rat neural. differentiation and tumor cell surface antigen gp130RB13-6. reveals relationship to human and murine PC-1.. Deissler H, Lottspeich F, Rajewsky MF;. J Biol Chem 1995;270:9849-9855.. [4]. 7982964. cDNA cloning of the human tumor motility-stimulating protein,. autotaxin, reveals a homology with phosphodiesterases.. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME,. Liotta LA, Stracke ML;. J Biol Chem 1994;269:30479-30484. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

PRK13759 family protein

Date:

2017-03-02

Date:

2022-02-18