Protein Family Models

This entry represents the C-terminal domain of GH85 endohexosaminidases.These enzymes cleave the glycosidic linkage between the two N-acetylglucosamine units that make up the chitobiose core of N-glycans. The C-terminal domain adopts a typical fibronectin Ig-like fold [1]. Paper describing PDB structure 2w91. [1]. 19181667. Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. Abbott DW, Macauley MS, Vocadlo DJ, Boraston AB;. J Biol Chem. 2009;284:11676-11689. (from Pfam)

Date:

2024-10-28

This galactose-binding domain is found in Sialidase from Micromonospora viridifaciens (NedA), which releases sialic acids for use as carbon and energy sources. This domain shows a jelly-roll topology [3]. Paper describing PDB structure 1czs. [1]. 10586886. Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P;. Nature. 1999;402:434-439. Paper describing PDB structure 1d7p. [2]. 10586887. Structure of the C2 domain of human factor VIII at 1.5 A resolution. Pratt KP, Shen BW, Takeshima K, Davie EW, Fujikawa K, Stoddard BL;. Nature. 1999;402:439-442. Paper describing PDB structure 1eut. [3]. 8591030. The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll. Gaskell A, Crennell S, Taylor G;. Structure. 1995;3:1197-1205. Paper describing PDB structure 1gof. [4]. 2002850. Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase. Ito N, Phillips SE, Stevens C, Ogel ZB, McPherson MJ, Keen JN, Yadav KD, Knowles PF;. Nature 1991;350:87-90. Paper describing PDB structure 1iqd. [5]. 11418455. Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII. Spiegel PC Jr, Jacquemin M, Saint-Remy JM, Stoddard BL, Pratt KP;. Blood. 2001;98:13-19. (from Pfam)

Date:

2024-10-16

This entry is composed of PKD domains found in bacterial surface proteins. (from Pfam)

Date:

2024-08-14

Family of endo-beta-N-acetylglucosaminidases. These enzymes work on a broad spectrum of substrates. (from Pfam)

Date:

2024-11-04

This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold [1]. [1]. 7736581. Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium;. Cell. 1995;81:289-298. [2]. 9889186. The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C;. EMBO J 1999;18:297-305. (from Pfam)

Date:

2024-10-16

This domain is also known as the discoidin (DS) domain family [1]. Extension of family to prokaryotes. [1]. 9684896. The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction. Baumgartner S, Hofmann K, Chiquet-Ehrismann R, Bucher P;. Protein Sci 1998;7:1626-1631. (from Pfam)

Date:

2024-10-16