This family includes the Helicobacter pylori protein CagE Swiss:Q48252, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system. The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration [1]. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro [2]. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE Swiss:P54910 and VirB Swiss:P05353 proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. Homologues of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis Swiss:Q9RPY1. [1]. 11104802. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, Yoshida H, Shiratori Y, Omata M;. J Exp Med 2000;192:1601-1610. [2]. 11447179. Epithelial Intestinal Cell Apoptosis Induced by Helicobacter pylori Depends on Expression of the cag Pathogenicity Island Phenotype. Le'Negrate G, Ricci V, Hofman V, Mograbi B, Hofman P, Rossi B;. Infect Immun 2001;69:5001-5009. [3]. 10438776. Essential components of the Ti plasmid trb system, a type IV macromolecular transporter. Li PL, Hwang I, Miyagi H, True H, Farrand SK;. J Bacteriol 1999;181:5033-5041. (from Pfam)
GO Terms:- Date:
- 2024-10-16