Protein Family Models

This entry represents the C-terminal domain found in a group of TetR transcription regulators, including YxaF (also known as T1414) [1] and LmrA from Bacillus subtilis, which are paralogous to each other [2]. LmrA and YxaF are repressors that bind specifically to almost the same cis sequences, LmrA/YxaF boxes, located in the promoter regions of the lmrAB operon, the yxaF gene, and the yxaGH operon [2]. Paper describing PDB structure 1sgm. [1]. 16475182. Crystal structure of a putative HTH-type transcriptional regulator yxaF from Bacillus subtilis. Seetharaman J, Kumaran D, Bonanno JB, Burley SK, Swaminathan S;. Proteins. 2006;63:1087-1091. [2]. 17483215. Dual regulation of the Bacillus subtilis regulon comprising the lmrAB and yxaGH operons and yxaF gene by two transcriptional repressors, LmrA and YxaF, in response to flavonoids. Hirooka K, Kunikane S, Matsuoka H, Yoshida K, Kumamoto K, Tojo S, Fujita Y;. J Bacteriol. 2007;189:5170-5182. (from Pfam)

Date:

2024-10-16

This domain is found in TetR-type regulators such as AcuR, acrylate-responsive repressor of acuR-acuI-dddL operons involved in acrylate catabolism [1]. [1]. 21249136. Unusual regulation of a leaderless operon involved in the catabolism of dimethylsulfoniopropionate in Rhodobacter sphaeroides. Sullivan MJ, Curson AR, Shearer N, Todd JD, Green RT, Johnston AW;. PLoS One. 2011;6:e15972. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Date:

2024-04-09