Protein Family Models

This C-terminal region of CcmF, one of the cytochrome c-type biogenesis proteins, is associated at the C-terminal with Cytochrome_C_asm family Pfam:PF01578. It is possible that it is this domain which delivers reductant to haem on CcmE. [1]. 20382024. Cytochrome c biogenesis: the Ccm system. Sanders C, Turkarslan S, Lee DW, Daldal F;. Trends Microbiol. 2010;18:266-274. [2]. 21958041. Cytochrome c biogenesis System I. Stevens JM, Mavridou DA, Hamer R, Kritsiligkou P, Goddard AD, Ferguson SJ;. FEBS J. 2011;278:4170-4178. [3]. 22723177. Continued surprises in the cytochrome c biogenesis story. Sawyer EB, Barker PD;. Protein Cell. 2012;3:405-409. (from Pfam)

Date:

2024-10-16

This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium[3], CcmC from E. coli and Paracoccus denitrificans [2,1] and orf240 from wheat mitochondria [4]. The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an ABC (ATP binding cassette) transporter complex. It is also proposed that this transporter is necessary for transport of some component needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif [3], orf240 also contains a putative heme-binding motif and is a proposed ABC transporter with c-type heme as its proposed substrate [4]. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither [1]. CcmF forms a working module with CcmH and CcmI, CcmFHI, and itself is unlikely to bind haem directly [5]. [1]. 9043133. The Paracoccus denitrificans ccmA, B and C genes: cloning and sequencing, and analysis of the potential of their products to form a haem or apo-c-type cytochrome transporter. Page D, Pearce DA, Norris HA, Ferguson SJ;. Microbiology 1997;143:563-576. [2]. 7635817. Escherichia coli genes required for cytochrome c maturation. Thony-Meyer L, Fischer F, Kunzler P, Ritz D, Hennecke H;. J Bacteriol 1995;177:4321-4326. [3]. 7665469. Characterization of the cycHJKL genes involved in cytochrome c biogenesis and symbiotic nitrogen fixation in Rhizobium leguminosarum. Delgado MJ, Yeo. TRUNCATED at 1650 bytes (from Pfam)

Gene:

ccsA

Date:

2024-10-16

With NrfF and NrfG catalyzes the insertion of heme into cytochrome c552

Gene:

nrfE

Date:

2020-10-26

heme lyase CcmF/NrfE family subunit such as cytochrome c-type biogenesis protein CcmF

Date:

2023-05-26

The product of this gene is required for the biogenesis of C-type cytochromes. This gene is thought to have eleven transmembrane helices. Disruption of this gene in Paracoccus denitrificans, encoding a putative transporter, results in formation of an unstable apocytochrome c and deficiency in siderophore production.

Date:

2024-06-11