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2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis) [1]. [1]. 10694574. Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate. Herz S, Wungsintaweekul J, Schuhr CA, Hecht S, Luttgen H, Sagner S, Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F;. Proc Natl Acad Sci U S A 2000;97:2486-2490. (from Pfam)
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with the corresponding release of cytidine 5-monophosphate (CMP)
Members of this protein family are 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, the IspF protein of the deoxyxylulose (non-mevalonate) pathway of IPP biosynthesis. This protein occurs as an IspDF bifunctional fusion protein in about 20 percent of bacterial genomes.
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