Protein Family Models

This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.41, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria. [1]. 10600651. Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme. Abbadi A, Brummel M, Schutt BS, Slabaugh MB, Schuch R, Spener F;. Biochem J 2000;345:153-160. (from Pfam)

Date:

2024-10-16

The members of this family are described as 3-ketoacyl-CoA synthases, type III polyketide synthases, fatty acid elongases and fatty acid condensing enzymes, and are found in both prokaryotic and eukaryotic (mainly plant) species. The region featured in this family contains the active site residues, as well as motifs involved in substrate binding [1]. [1]. 12139488. Alteration of reaction and substrate specificity of a bacterial type III polyketide synthase by site-directed mutagenesis. Funa N, Ohnishi Y, Ebizuka Y, Horinouchi S;. Biochem J 2002;367:781-789. (from Pfam)

Date:

2024-10-16

This domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain. [1]. 10426957. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP;. Nat Struct Biol 1999;6:775-784. (from Pfam)

Date:

2024-10-16

The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain. [1]. 10426957. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP;. Nat Struct Biol 1999;6:775-784. (from Pfam)

Date:

2024-10-16

type III polyketide synthase (PKS) is a homodimeric iterative PKS that contains two independent active sites each of which catalyzes single or multiple condensation reactions to generate polyketides of different lengths, similar to chalcone and stilbene synthase, which are involved in the synthesis of chalcone or stilbene, respectively, by catalyzing the addition of three molecules of malonyl-CoA to a starter CoA ester

Date:

2024-10-01