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1.

C-terminal topoisomerase domain

This domain is found at the C-terminal of topoisomerase and other similar enzymes. (from Pfam)

Date:
2024-08-14

Family Accession:
NF025728.5
Method:
HMM

2.

Eukaryotic DNA topoisomerase I, DNA binding fragment

Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2]. This family may be more than one structural domain. [1]. 7770916. The mechanisms of DNA topoisomerases. Roca J;. Trends Biochem Sci 1995;20:156-160. [2]. 9488644. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG;. Science 1998;279:1504-1513. (from Pfam)

GO Terms:
Molecular Function:
DNA binding (GO:0003677)
Molecular Function:
DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917)
Biological Process:
DNA topological change (GO:0006265)
Date:
2024-10-16

Family Accession:
NF014916.5
Method:
HMM

3.

Eukaryotic DNA topoisomerase I, catalytic core

Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2]. [1]. 7770916. The mechanisms of DNA topoisomerases. Roca J;. Trends Biochem Sci 1995;20:156-160. [2]. 9488644. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG;. Science 1998;279:1504-1513. (from Pfam)

GO Terms:
Molecular Function:
DNA binding (GO:0003677)
Molecular Function:
DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917)
Biological Process:
DNA topological change (GO:0006265)
Date:
2024-10-16

Family Accession:
NF013215.5
Method:
HMM

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