Protein Family Models

Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology according to [1] or an OB fold according to ECOD. [1]. 7628012. Structure of the bacteriophage Mu transposase core: a common structural motif for DNA transposition and retroviral integration. Rice P, Mizuuchi K;. Cell. 1995;82:209-220. (from Pfam)

Date:

2024-10-21

Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1]. [1]. 7801124. Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases [see comments]. Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR;. Science 1994;266:1981-1986. (from Pfam)

Date:

2024-10-16

original name: IS21-like ISAs29 family transposase

Gene:

istA

Date:

2023-10-03

IS21/IS408/IS1162 family transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Date:

2024-12-09

Gene:

istA

Date:

2021-03-03

Date:

2019-09-10

Date:

2019-09-10