Protein Family Models for Protein (Select 2490832503) - Protein Family Models

Select item 4139431.

DNA gyrase C-terminal beta-propeller domain-containing protein

This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure [1]. This region has been shown to bind DNA non-specifically and may stabilise the DNA-topoisomerase complex [2]. [1]. 11948780. C-terminal domain of gyrase A is predicted to have a beta-propeller structure. Qi Y, Pei J, Grishin NV;. Proteins 2002;47:258-264. [2]. 1657531. DNA gyrase: structure and function. Reece RJ, Maxwell A;. Crit Rev Biochem Mol Biol 1991;26:335-375. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase activity (GO:0003916)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2024-10-16

Family Accession:: NF015922.5
Method:: HMM

Select item 4113782.

DNA gyrase subunit A

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2024-08-14

Family Accession:: NF012731.5
Method:: HMM

Select item 3938003.

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Family Accession:

Select item 3883284.

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Family Accession:

Select item 3508295.

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Family Accession:

Select item 3468096.

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Family Accession:

Select item 2306927.

DNA topoisomerase IV subunit A

DNA topoisomerase IV subunit A is part of topoisomerase IV that is essential for chromosome segregation; it relaxes supercoiled DNA and performs the decatenation events required during the replication of a circular DNA molecule

Date:: 2022-08-18

Family Accession:: 11481105
Method:: Sparcle

Select item 359648.

DNA topoisomerase (ATP-hydrolyzing)

This HMM identifies type II DNA topoisomerases such as ParC (DNA topoisomerase IV subunit A) and GyrA (DNA gyrase subunit A).

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2023-06-29

Family Accession:: NF004044.1
Method:: HMM

Select item 256449.

DNA topoisomerase IV subunit A

Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason.

Gene:: parC

GO Terms:

Molecular Function:: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity (GO:0003918)

Biological Process:: DNA topological change (GO:0006265)

Cellular Component:: DNA topoisomerase IV complex (GO:0009340)

Date:: 2021-04-27

Family Accession:: TIGR01062.1
Method:: HMM

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