Protein Family Models

The members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses; glycogen, starch, glucan or maltodextrin. [1]. 1304390. Control of phosphorylase b conformation by a modified cofactor: crystallographic studies on R-state glycogen phosphorylase reconstituted with pyridoxal 5'-diphosphate. Leonidas DD, Oikonomakos NG, Papageorgiou AC, Acharya KR, Barford D, Johnson LN;. Protein Sci 1992;1:1112-1122. (from Pfam)

Date:

2024-10-16

glycogen/starch/alpha-glucan phosphorylase uses phosphate to catalyze the cleavage of alpha 1,4-linkages between pairs of glucose residues at the end of glucose polymers or oligomers, releasing alpha-D-glucose 1-phosphate

Date:

2022-08-20

This family consists of phosphorylases. Members use phosphate to break alpha 1,4 linkages between pairs of glucose residues at the end of long glucose polymers, releasing alpha-D-glucose 1-phosphate. The nomenclature convention is to preface the name according to the natural substrate, as in glycogen phosphorylase, starch phosphorylase, maltodextrin phosphorylase, etc. Name differences among these substrates reflect differences in patterns of branching with alpha 1,6 linkages. Members include allosterically regulated and unregulated forms. A related family, TIGR02094, contains examples known to act well on particularly small alpha 1,4 glucans, as may be found after import from exogenous sources.

Gene:

glgP

Date:

2024-05-29