Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
TA system toxin CbtA family protein
CbtA is a family of bacterial and archaeal toxins of type IV toxin-antitoxin system. Toxins from such systems in free-living bacteria inhibit cell growth by targeting essential functions of cellular metabolism [1]. In this case the toxin inhibits cell-division leading to changes in morphology and finally lysis, by interacting with two essential cytoskeletal proteins, FtsZ and MreB. For FtsZ it inhibits its GTPase activity and GTP-dependent polymerisation, and for MreB it inhibits its ATP-dependent polymerisation. These actions of CbtA appear to occur simultaneously [2]. he cognate antitoxin family is represented by Pfam:PF06154. [1]. 14594833. A novel family of Escherichia coli toxin-antitoxin gene pairs. Brown JM, Shaw KJ;. J Bacteriol. 2003;185:6600-6608. [2]. 21166897. YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB. Tan Q, Awano N, Inouye M;. Mol Microbiol. 2011;79:109-118. (from Pfam)
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on