Protein Family Models

This domain is found at the C-terminal end of DesT from Pseudomonas aeruginosa and similar bacterial transcriptional regulators. DesT is involved in the control of the unsaturated:saturated fatty acid ratio available for membrane lipid synthesis. This region folds into six helices that create the ligand-binding domain [1]. It is normally found associated with Pfam:PF00440. Paper describing PDB structure 3lsj. [1]. 20639888. Structural basis for the transcriptional regulation of membrane lipid homeostasis. Miller DJ, Zhang YM, Subramanian C, Rock CO, White SW;. Nat Struct Mol Biol. 2010;17:971-975. Paper describing PDB structure 6o6n. [2]. 32710080. Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. Lara J, Diacovich L, Trajtenberg F, Larrieux N, Malchiodi EL, Fernandez MM, Gago G, Gramajo H, Buschiazzo A;. Nat Commun. 2020;11:3703. (from Pfam)

Date:

2024-10-16

This is the C-terminal domain found in putative transcriptional regulator, TetR family proteins. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Date:

2024-04-09