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PKD domain-containing protein
This entry is composed of PKD domains found in bacterial surface proteins. (from Pfam)
BT_3987 domain-containing protein
This domain, previously known as DUF1735, is found in a number of proteins mainly found in firmicutes, including BT_3987 from Bacteroides thetaiotaomicron, which displays hydrolytic activity against Hy-type N-glycans, probably initiating the degradation of this type of glycan in the human gut [1]. This domain adopts a beta-sandwich fold. [1]. 34324829. GH18 endo-beta-N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans. Trastoy B, Du JJ, Li C, Garcia-Alija M, Klontz EH, Roberts BR, Donahue TC, Wang LX, Sundberg EJ, Guerin ME;. J Biol Chem. 2021;297:101011. [2]. 34420703. Discrete genetic loci in human gut Bacteroides thetaiotaomicron confer pectin metabolism. Li M, Li S, Guo X, Guo C, Wang Y, Du Z, Zhang Z, Xie C, Ding K;. Carbohydr Polym. 2021;272:118534. (from Pfam)
This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold [1]. [1]. 7736581. Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. The International Polycystic Kidney Disease Consortium;. Cell. 1995;81:289-298. [2]. 9889186. The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease. Bycroft M, Bateman A, Clarke J, Hamill SJ, Sandford R, Thomas RL, Chothia C;. EMBO J 1999;18:297-305. (from Pfam)
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