Protein Family Models

Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease [2]. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold. [1]. 24007199. Protein substrates of a novel secretion system are numerous in the Bacteroidetes phylum and have in common a cleavable C-terminal secretion signal, extensive post-translational modification, and cell-surface attachment. Veith PD, Nor Muhammad NA, Dashper SG, Likic VA, Gorasia DG, Chen D, Byrne SJ, Catmull DV, Reynolds EC;. J Proteome Res. 2013;12:4449-4461. [2]. 22593568. PG0026 is the C-terminal signal peptidase of a novel secretion system of Porphyromonas gingivalis. Glew MD, Veith PD, Peng B, Chen YY, Gorasia DG, Yang Q, Slakeski N, Chen D, Moore C, Crawford S, Reynolds EC;. J Biol Chem. 2012;287:24605-24617. (from Pfam)

Date:

2024-10-16

Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see Pfam:PF00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567. (from Pfam)

Date:

2024-08-14

Type IX secretions systems (T9SS) occur in the Bacteroidetes, such as Cytophaga hutchinsonii and Flavobacterium johnsoniae, and are required for the type of gliding motility seen in that lineage, although they are not limited processing target proteins from that system. The C-terminal domain described by TIGR04183, recognized as sorting signal by T9SS, is now known as type A, and is quite distinct from type B (see TIGR04131). Most targets of T9SS are cleaved by a transpeptidase and then attached to a component of the outer membrane, but a few are released in soluble form.

Date:

2023-07-13

S8 family peptidase is a subtilisin-like serine protease containing a Asp/His/Ser catalytic triad that is not homologous to trypsin

Date:

2022-11-08