Protein Family Models

This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1). It is thought to constitute part of the catalytic core of ATP dependent DNA ligase [1]. [1]. 9016621. Domain structure of vaccinia DNA ligase. Sekiguchi J, Shuman S;. Nucleic Acids Res 1997;25:727-734. (from Pfam)

Date:

2024-10-16

This domain belongs to a more diverse superfamily, including Pfam:PF01331 and Pfam:PF01653 [3]. [1]. 8653795. Crystal structure of an ATP-dependent DNA ligase from bacteriophage T7. Subramanya HS, Doherty AJ, Ashford SR, Wigley DB;. Cell 1996;85:607-615. [2]. 9363683. Mammalian DNA ligases. Tomkinson AE, Levin DS;. Bioessays 1997;19:893-901. [3]. 10222208. Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. Aravind L, Koonin EV;. J Mol Biol 1999;287:1023-1040. (from Pfam)

Date:

2024-10-16

DNA repair of double-stranded breaks by non-homologous end joining (NHEJ) is accomplished by a two-protein system that is present in a minority of prokaryotes. One component is the Ku protein (see TIGR02772), which binds DNA ends. The other is a DNA ligase, a protein that is a multidomain polypeptide in most of those bacteria that have NHEJ, a permuted polypeptide in Mycobacterium tuberculosis and a few other species, and the product of tandem genes in some other bacteria. This model represents the ligase domain.

Gene:

ligD

Date:

2021-08-24