Protein Family Models

This domain is functionally uncharacterised, found at the N-terminal of the uncharacterised UPF0758 proteins from bacteria and archaea, and is approximately 90 amino acids in length. UPF0758 was previously known as the radC family, a name that was assigned according to the radC102 mutant of E. coli which was later demonstrated to be an allele of the transcription-repair-coupling factor recG [1, 2]. UPF0758 has been described as a putative JAMM-family deubiquitinating enzyme, but its function remains to be determined [3]. Structure prediction using Colab notebook from AlphaFold DB suggests that it has an alpha bundle fold. It may contain two helix-hairpin-helix (HhH) motifs. This domain is found in association with Pfam:PF04002 [4]. [1]. 11053371. radC102 of Escherichia coli is an allele of recG. Lombardo MJ, Rosenberg SM;. J Bacteriol. 2000;182:6287-6291. [2]. 18556794. RadC, a misleading name?. Attaiech L, Granadel C, Claverys JP, Martin B;. J Bacteriol. 2008;190:5729-5732. [3]. 14737182. JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. Ambroggio XI, Rees DC, Deshaies RJ;. PLoS Biol. 2004;2:E2. [4]. 21890906. Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems. Iyer LM, Zhang D, Rogozin IB, Aravind L;. Nucleic Acids Res. 2011; [Epub ahead of print] (from Pfam)

Date:

2024-10-16

JAB or Mpr1p, Pad1p N-terminal (MPN) domain-containing protein contains the signature JAB1/MPN/Mov34 metalloenzyme (JAMM) motif, which is involved in zinc ion coordination; a function as a nuclease has been suggested

Date:

2024-12-18