Protein Family Models

This entry represents probable choline-binding cell wall repeats. (from Pfam)

Date:

2024-10-16

Pair of presumed choline-binding repeats often found adjacent to Pfam:PF01473. (from Pfam)

Date:

2024-08-14

this entry contains a pair of presumed choline-binding repeats that are often found adjacent to Pfam:PF01473. [1]. 27917891. Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis. Gutierrez-Fernandez J, Saleh M, Alcorlo M, Gomez-Mejia A, Pantoja-Uceda D, Trevino MA, Voss F, Abdullah MR, Galan-Bartual S, Seinen J, Sanchez-Murcia PA, Gago F, Bruix M, Hammerschmidt S, Hermoso JA;. Sci Rep. 2016;6:38094. (from Pfam)

Date:

2024-10-16

These repeats are characterised by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins. The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls [1]. Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding [2] as well as in the related dextransucrases of Leuconostoc mesenteroides. Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known. [1]. 3422470. Molecular evolution of lytic enzymes of Streptococcus pneumoniae and its bacteriophages. Garcia E, Garcia JL, Garcia P, Arraras A, Sanchez-Puelles JM, Lopez R;. Proc Natl Acad Sci U S A 1988;85:914-918. [2]. 14527392. Structural basis for selective recognition of pneumococcal cell wall by modular endolysin from phage Cp-1. Hermoso JA, Monterroso B, Albert A, Galan B, Ahrazem O, Garcia P, Martinez-Ripoll M, Garcia JL, Menendez M;. Structure (Camb) 2003;11:1239-1249. [3]. 7860591. Tracking the evolution of the bacterial choline-binding domain: molecular characterization of the Clostridium acetobutylicum NCIB 8052 cspA gene. Sanchez-Beato AR, Ronda C, Garcia JL;. J Bacteriol 1995;177:1098-1103. [4]. 1830357. A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences. Wren BW;. Mol Microbiol 1991;5:797-803. [5]. 2307516. Sequence analysis of the gene. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16