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nucleotide disphospho-sugar-binding domain-containing protein
This domain is found at the C-terminal of Erythromycin biosynthesis protein CIII (EryCIII) from Saccharopolyspora erythraea and similar proteins found in bacteria and eukaryotes. This protein is organised into two domains, both of them with a Rossmann-like alpha/beta fold. The C-terminal domain contains the nucleotide disphospho-sugar (NDP-sugar) binding site [1]. [1]. 22056329. Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII. Moncrieffe MC, Fernandez MJ, Spiteller D, Matsumura H, Gay NJ, Luisi BF, Leadlay PF;. J Mol Biol. 2012;415:92-101. (from Pfam)
glycosyltransferase
The sequences scoring highest to this HMM are C-terminal regions of MurG enzymes (undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase), including the UDP-GlcNAc binding site. Those enzymes belong to glycosyltransferase family 28, but lower scoring members of this family include glycosyltransferases from other families that transfer different sugars.
UDP-glucoronosyl and UDP-glucosyl transferase
macrolide family glycosyltransferase
This model describes the MGT (macrolide glycosyltransferase) subfamily of the UDP-glucuronosyltransferase family. Members include a number of glucosyl transferases for macrolide antibiotic inactivation, but also include transferases of glucose-related sugars for macrolide antibiotic production.
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