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TIR domain-containing protein
This is a family of Toll-like receptors. (from Pfam)
toll/interleukin-1 receptor domain-containing protein
The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (Swiss:Q99836) and TOLLIP (Toll interacting protein, Swiss:Q9H0E2). In turn, these associate with various kinases to set off signalling cascades [3]. [1]. 9013863. The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE;. FEBS Lett 1997;402:81-84. [2]. 9237759. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [see comments]. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr;. Nature 1997;388:394-397. [3]. 12186654. Toll-like receptors: a family of pattern-recognition receptors in mammals. Armant MA, Fenton MJ;. Genome Biol 2002;3:REVIEWS3011. (from Pfam)
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