Protein Family Models

This domain is found within the sporulation regulator WhiA. It is a LAGLIDADG superfamily like domain [1-2]. [1]. 17603302. Bacterial DUF199/COG1481 Proteins Including Sporulation Regulator WhiA are Distant Homologs of LAGLIDADG Homing Endonucleases That Retained Only DNA Binding. Knizewski L, Ginalski K;. Cell Cycle. 2007;6:1666-1670. [2]. 19836336. The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease. Kaiser BK, Clifton MC, Shen BW, Stoddard BL;. Structure. 2009;17:1368-1376. (from Pfam)

Date:

2024-10-16

This domain is found at the N terminal of sporulation factor WhiA. This domain is related to the LAGLIDADG Homing endonuclease domain while the C terminal domain of WhiA is predicted to be a DNA binding helix-turn-helix domain [2]. [1]. 10986251. WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2). Ainsa JA, Ryding NJ, Hartley N, Findlay KC, Bruton CJ, Chater KF;. J Bacteriol. 2000;182:5470-5478. [2]. 17603302. Bacterial DUF199/COG1481 Proteins Including Sporulation Regulator WhiA are Distant Homologs of LAGLIDADG Homing Endonucleases That Retained Only DNA Binding. Knizewski L, Ginalski K;. Cell Cycle. 2007;6:1666-1670. [3]. 19836336. The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease. Kaiser BK, Clifton MC, Shen BW, Stoddard BL;. Structure. 2009;17:1368-1376. (from Pfam)

Date:

2024-10-16

This domain is found at the C-terminus of the sporulation regulator WhiA. It is predicted to form a DNA-binding helix-turn-helix structure [2]. The WhiA protein also contains two N-terminal domains that are distant homologues of LAGLIDADG homing endonucleases [2]. [1]. 10986251. WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2). Ainsa JA, Ryding NJ, Hartley N, Findlay KC, Bruton CJ, Chater KF;. J Bacteriol. 2000;182:5470-5478. [2]. 17603302. Bacterial DUF199/COG1481 Proteins Including Sporulation Regulator WhiA are Distant Homologs of LAGLIDADG Homing Endonucleases That Retained Only DNA Binding. Knizewski L, Ginalski K;. Cell Cycle. 2007;6:1666-1670. [3]. 19836336. The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease. Kaiser BK, Clifton MC, Shen BW, Stoddard BL;. Structure. 2009;17:1368-1376. (from Pfam)

Date:

2024-10-16

This family describes a DNA-binding protein widely conserved in Gram-positive bacteria, and occasionally occurring elsewhere, such as in Thermotoga. It is associated with cell division, and in sporulating organisms with sporulation.

Gene:

whiA

Date:

2021-07-29