Protein Family Models

This entry includes the catalytic domain of HGSNAT (Heparan-alpha-glucosaminide N-acetyltransferase). It contains the conserved histidine in the active site (His269), thought to hold the acetyl group during the transfer across the membrane and required for its enzymatic activity. HGSNAT transfers an acetyl group from cytoplasmically derived acetyl-CoA to terminal N-glucosamine residues of heparan sulfate within the lysosomes [1]. [1]. 20650889. Analysis of the biogenesis of heparan sulfate acetyl-CoA:alpha-glucosaminide N-acetyltransferase provides insights into the mechanism underlying its complete deficiency in mucopolysaccharidosis IIIC. Durand S, Feldhammer M, Bonneil E, Thibault P, Pshezhetsky AV;. J Biol Chem. 2010;285:31233-31242. (from Pfam)

Date:

2024-10-16

This family includes a range of acyltransferase enzymes. This domain is found in a wide range of acyltransferase enzymes, including, mainly, bacterial proteins which catalyse the transfer of acyl groups, other than amino-acyl, from one compound to another, such as Glucans biosynthesis protein C (OPGC) or protein OatA from Listeria monocytogenes serovar 1/2a and Staphylococcus aureus, an integral membrane protein which is responsible for O-acetylation at the C6-hydroxyl group of N-acetylmuramyl residues, forming the corresponding N,6-O-diacetylmuramic acid of the peptidoglycan, a modification that determines lysozyme resistance [1,2]. This domain is also present in eukaryotic proteins, namely O-acyltransferase like protein (OACYL) from mouse and RHY1 (Regulator of hypoxia-inducible factor 1) [3] and NRF6 (Nose resistant to fluoxetine protein 6) from Caenorhabditis elegans [4]. [1]. 21844299. OatA, a peptidoglycan O-acetyltransferase involved in Listeria monocytogenes immune escape, is critical for virulence. Aubry C, Goulard C, Nahori MA, Cayet N, Decalf J, Sachse M, Boneca IG, Cossart P, Dussurget O;. J Infect Dis. 2011;204:731-740. [2]. 32350117. Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus. Jones CS, Sychantha D, Howell PL, Clarke AJ;. J Biol Chem. 2020;295:8204-8213. [3]. 16980385. The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1. Shen C, Shao Z, Powell-Coffman JA;. Genetics. 2006;174:1205-1214. [4]. 16118202. Fluoxetine-resistance genes in Caenorhabditi. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16